We will use our twin/adoption design with polygenic score data (PGS), detailed cognitive batteries, physical health, proposed biomarkers of accelerated aging that may participate in immune- inflammatory and neurotransmitter pathways, and neighborhood features to shed light on risk-resilience factors that account for midlife cognitive stability and change.
As we leverage data from prior assessments with CATSLife1, the opportunity to investigate the transition across midlife with CATSLife2 is ideal.
Colorado adoption project findings full#
As participants transition to midlife, we will leverage powerful design features and a wealth of prospective data collected from infancy through adulthood, including a full adoption design, to examine causal implications of early environmental risk and protective factors, and a twin design to examine environmental factors that may have causal influence on cognition, controlling for familial confounds. Further, we propose to integrate the prospective Twins Early Development Study (TEDS) with a new assessment of 5000 twins at age 28 years, allowing us to build on over 20 years of prior data collection, including genome-wide genotyping, to explore similar predictors of cognitive maintenance. Whereas CATSLife1 established baseline performance as participants prepare for transitions to midlife, CATSLife2 proposes to evaluate stability and change across the midlife transition. We propose a 5-year follow-up of 1400 adoptive and nonadoptive probands, siblings, and twins as they navigate the transition to midlife at ages 33-50 years (CATSLife2). CATSLife comprises the prospective Colorado Adoption Project (CAP) and parallel Longitudinal Twin Study (LTS), now tested at ages 28-45 years (CATSLife1). The Colorado Adoption/Twin Study of Lifespan behavioral development and cognitive aging (CATSLife) seeks a greater understanding of the environmental and genetic factors that drive increasing divergence in cognitive maintenance.
Emerging evidence suggests that individual differences in cognitive aging unfold across a lifetime however, relatively little is known as to how early life versus proximal influences accumulate to impact cognitive functioning across midlife.
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